Association of salivary nitric oxide metabolites with dry mouth and hyposalivation among Korean adults

nitric oxide;dry mouth;hyposalivation;adult;epidemiology;산화질소;구강건조증;침분비저하;성인;역학;617

치과대학 치의과학과 ;

University:서울대학교 대학원

关键词: nitric oxide;    dry mouth;    hyposalivation;    adult;    epidemiology;    산화질소;    구강건조증;    침분비저하;    성인;    역학;    617;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/131138/1/000000020937.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

firstly, hyposalivation is associated with DM, secondly, salivary NO is associated with DM and finally, salivary NO is associated with hyposalivation. The aim of this study was to evaluate these three hypothese among Korean adults.Materials and Methods: The study sample consisted of 293 participants from Sunchang Longevity Cohort. DM was assessed by single question and Visual Analog Scale (VAS). Hyposalivation was determined by resting salivary flow rate < 0.1 ml/min. Salivary NO metabolites (total, nitrite [NO2-], nitrate [NO3-]) were measured via the Griess reaction. Age, sex, economic level, exercise, smoking, drinking, obesity, diabetes and food habits were considered as confounders. Multivariable logistic regression analysis was applied to estimate the association. Stratified analysis by age, sex, economic level, exercise, smoking, drinking, obesity, diabetes, sour and salty food was also applied.Results: The association between DM and hyposalivation was not significant (p=0.473). High level of nitrate compared to low level of nitrate was associated with low prevalence of DM (adjusted OR= 0.51, 95% CI: 0.27-0.97). The link was highlighted on males (OR= 0.27), non-obese people (OR= 0.40), non-diabetic people (OR=0.40) and drinkers (OR=0.20). High level of nitrate compared to low level of nitrate was associated with high prevalence of hyposalivation (adjusted OR= 2.05, 95% CI: 1.05-4.00). The link was highlighted on elders under 70 years (OR=3.00), non-exercisers (OR=2.48) and obese people (OR=4.17).Conclusions: Our data showed that there was no significant association between dry mouth and hyposalivation. High level of nitric oxide metabolite is independently associated with low prevalence of dry mouth discomfort and high prevalence of hyposalivation among Korean adults. Further studies will be needed to clarify the causality and mechanism of this link.