Candidemia in Children with Malignancies: Report from the Infection Working Group of the Hellenic Society of Pediatric Hematology-Oncology

Journal of Fungi

卷:6

Eugenia Papakonstantinou¹  Kondilia Antoniadi²  Eleni Vasileiou³  Athanasios Tragiannidis³  Apostolos Pourtsidis⁴  Margarita Baka⁴  Vasiliki Galani⁵  Nikolaos Katzilakis⁶  Efthichia Stiakaki⁶  Charoula Tsipou⁷  Antonios Kattamis⁷  Elda Ioannidou⁸  Vasiliki Kitra⁸  Anna Paisiou⁸ 

[1] Department of Pediatric Hematology and Oncology, Hippokration Hospital, 546 42 Thessaloniki, Greece;

[2] Department of Pediatric Hematology-Oncology, Aghia Sophia Children’s Hospital, 115 27 Athens, Greece;

[3] Hematology-Oncology Unit, 2nd Department of Pediatrics, Aristotle University of Thessaloniki, AHEPA Hospital, 546 36 Thessaloniki, Greece;

[4] Oncology Department, P. and A. Kyriakou Children’s Hospital, 115 27 Athens, Greece;

[5] Pediatric Hematology Oncology Department, Mitera Children’s Hospital, 151 23 Athens, Greece;

[6] Pediatric Hematology Oncology Department, University of Crete, 700 13 Heraklion, Greece;

[7] Pediatric Hematology-Oncology Unit, 1st Department of Pediatrics, National and Kapodistrian University of Athens, Aghia Sophia Children’s Hospital, 115 27 Athens, Greece;

[8] Stem Cell Transplant Unit, Aghia Sophia Children’s Hospital, 115 27 Athens, Greece;

关键词: candida;    candidemia;    hematology;    oncology;    pediatric;    epidemiology;   

DOI  :  10.3390/jof6040276

来源: DOAJ

【 摘 要 】

Candidemia is an important cause of morbidity and mortality especially in immunocompromised and hospitalized patients. We retrospectively collected data of candidemia cases that occurred in the seven Hematology-Oncology Departments/Units of Greece and the Stem Cell Transplant Unit between 2015 and 2019. In total, 19 episodes of candidemia in 19 patients were recorded. The majority of the patients (78.9%) had at least one risk factor for candidemia. The most frequent risk factors associated with candidemia observed in our patients were prolonged duration of hospitalization (30 days, range 1–141), presence of a central venous catheter at diagnosis of candidemia (73.7%) and antibiotics use during the last two weeks (84.2%). Candida parapsilosis was the most common species isolated accounting for 42.1%, followed by C. albicans (26.3%) and C. famata (15.8%). Nearly all of the patients (84.2%) received antifungal monotherapy with liposomal amphotericin B or echinocandins. The central venous catheter was removed in 78.6% of patients and the median time between the first positive blood culture and catheter removal was 3 days (range 1–9). Mortality at 28 days was 26.3%. In conclusion, a predominance of non-albicans species was observed in our study in conformity with the global trend.

【 授权许可】

Unknown