Impact of chitosan-based nanocarriers on cytoskeleton dynamics: Current status and challenges

Biocell

article

M. CAROLINA DI SANTO¹  AGUSTINA ALAIMO¹  ANA PAULA DOMÍNGUEZ RUBIO¹  OSCAR E. PÉREZ¹ 

[1] Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires;Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales

关键词: Cytoskeletal dynamics;    Cellular uptake;    Endocytosis;    Nanocarriers;    Chitosan;    Bioactive compounds;   

DOI  :  10.32604/biocell.2022.018391

学科分类：仪器

来源: Biocell

【 摘 要 】

Chitosan-based nanocarriers (CS-NCs) show a promising role in improving drugs and bioactive compounds delivery for therapy. However, the effects exerted by CS-NCs at the cellular level, including their recognition and uptake, have not been fully investigated yet. Many factors, including size, shape, concentration, and surface chemistry of CS-NCs, play an important role in determining the types of intracellular signals triggered. The mechanism of uptake and the involvement of the cytoskeleton during the CS-NCs endocytosis variates among the different cell types as well as further effects observed inside cells. In the present work, we discuss the effects induced by CS-NCs per se on the cytoskeleton, a key component in cell architecture and physiology. The focus of this report is made on tumoral and normal biological models in which CS-NCs could differentially affect the cell cytoskeleton. The recent years reports regarding the impact of CS-NCs on cytoskeleton dynamics and the current techniques for its evaluation are summarized and discussed. Understanding mechanisms underlying cytoskeletal impact after cell exposure to CS-NCs is critical for the design of safest value-added formulations in the biomedical field. Furthermore, this revision points out some interesting aspects of cytoskeletal changes and cell death encompassing anti-tumoral effects.

【 授权许可】

CC BY