Engineered nanoparticles interacting with cells: size matters

Journal of Nanobiotechnology

Review

Karin Nienhaus¹  Li Shang¹  Gerd Ulrich Nienhaus² 

[1] Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), Wolfgang-Gaede-Strasse 1, 76131, Karlsruhe, Germany;Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), Wolfgang-Gaede-Strasse 1, 76131, Karlsruhe, Germany;Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany;Department of Physics, University of Illinois at Urbana-Champaign, 61801, Urbana, IL, USA;

关键词: Nanoparticle;    Cellular uptake;    Protein corona;    Endocytosis;    Red blood cell;    Cytotoxicity;   

DOI  :  10.1186/1477-3155-12-5

 received in 2014-01-03, accepted in 2014-01-31,  发布年份 2014

来源: Springer

【 摘 要 】

With the rapid advancement of nanoscience and nanotechnology, detailed knowledge of interactions between engineered nanomaterials and cells, tissues and organisms has become increasingly important, especially in regard to possible hazards to human health. This review intends to give an overview of current research on nano-bio interactions, with a focus on the effects of NP size on their interactions with live cells. We summarize common techniques to characterize NP size, highlight recent work on the impact of NP size on active and passive cellular internalization and intracellular localization. Cytotoxic effects are also discussed.

【 授权许可】

Unknown   
© Shang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.