Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

Journal of Nanobiotechnology

Review

Shruti R Saptarshi¹  Andreas L Lopata¹  Albert Duschl² 

[1] Centre for Biodiscovery and Molecular Development of Therapeutics, School of Pharmacy and Molecular Science, James Cook University, Townsville, Queensland, Australia;Department of Molecular Biology, University of Salzburg, Salzburg, Austria;

关键词: Nanoparticle;    Protein corona;    Protein unfolding;    Nanoparticle uptake;    Circular dichroism;   

DOI  :  10.1186/1477-3155-11-26

 received in 2013-05-24, accepted in 2013-07-12,  发布年份 2013

来源: Springer

【 摘 要 】

Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein molecules which may affect the overall bio-reactivity of the nanoparticle. In depth understanding of such interactions can be directed towards generating bio-compatible nanomaterials with controlled surface characteristics in a biological environment. The main aim of this review is to summarise current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake.

【 授权许可】

Unknown   
© Saptarshi et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.