Gallbladder disease is associated with the risk of cardiovascular disease among Uyghurs in Xinjiang: a prospective cohort study

BMC Public Health

Research

Xiao Cheng¹  Shijie Zhang¹  Xinyu Peng¹  Jiajia Wang¹  Jing Yang¹  Xiangwei Wu¹  Hongwei Zhang¹  Rong Bai¹  Heng Guo²  Shuxia Guo²  Xianghui Zhang²  Rulin Ma² 

[1] Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shihezi University School of Medicine, 832000, Shihezi, China;Department of NHC Key Laboratory of Prevention and Treatment of Central, Asia High Incidence Diseases, The First Affiliated Hospital of Shihezi University School of Medicine, 832000, Shihezi, China;Department of NHC Key Laboratory of Prevention and Treatment of Central, Asia High Incidence Diseases, The First Affiliated Hospital of Shihezi University School of Medicine, 832000, Shihezi, China;Department of Public Health, Shihezi University School of Medicine, 832000, Shihezi, China;

关键词: Cardiovascular disease;    Gallbladder disease;    Cardiometabolic risk factors;    Cohort study;    Uyghur population;   

DOI  :  10.1186/s12889-023-15098-9

 received in 2022-10-10, accepted in 2023-01-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundGallbladder disease (GBD) can increase the risk of cardiovascular disease (CVD). However, GBD has rarely been reported in the less developed, rural areas of Xinjiang. This study aimed to determine the prevalence of GBD and incidence of CVD in a prospective cohort study in rural Xinjiang. Moreover, the study aimed to explore the association between GBD and CVD within this cohort.MethodsThe study cohort included 11,444 Uyghur adults in Xinjiang, 3rd division, from the 51st Mission. Study groups were classified according to whether GBD was present or absent at baseline. The occurrence of CVD was the end event. Demographic, anthropometric, and biochemical data were recorded, and the incidence of CVD in the GBD and non-GBD groups analysed. Cox proportional hazards regression models were used to assess the association between GBD and CVD and factors associated with their incidence. Several subgroup analyses were performed to assess CVD incidence in different subgroups. The interaction between GBD and cardiometabolic risk factors, and subsequent risk of developing CVD, was evaluated.ResultsPrevalence of GBD in the study cohort was 10.29%. After a median follow-up of 4.92 years, the cumulative incidence of CVD in the study cohort was 10.49%, 8.43% in males and 12.65% in females. CVD incidence was higher in the GBD group (34.04% vs. 7.78%, HR = 4.96, 95% CI: 4.40–5.59). After multivariate adjustment, the risk of CVD remained higher in the GBD group (HR = 2.89, 95% CI: 2.54–3.29). Subgroup analyses showed male sex, smoking, alcohol consumption, lack of exercise, and abnormal renal function were all associated with increased risk of CVD. Moreover, the risk of CVD was markedly higher in GBD combined with cardiometabolic risk factors (hypertension, T2DM, dyslipidaemia, overweight, and abdominal obesity), than in cardiometabolic risk factors alone and this was higher in the GBD group than in the non-GBD group regardless of whether cardiometabolic risk factors were combined.ConclusionGBD is an important independent risk factor for CVD development. Awareness of these associations will raise concerns among clinicians about the risk of cardiovascular disease in patients with GBD.

【 授权许可】

CC BY   
© The Author(s) 2023

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