The interrelationship and accumulation of cardiometabolic risk factors amongst young adults in the United Arab Emirates: The UAE Healthy Future Study

Diabetology & Metabolic Syndrome

Naima Oumeziane¹  Hamad Alblooshi¹  Marina Kazim¹  Habiba Alsafar²  Tom Loney³  Fatme Alanouti⁴  Abdulla Alnaeemi⁵  Micheal Weitzman⁶  Abderrahim Oulhaj⁷  Mohammad Hag Ali⁸  Juma Alkaabi⁹  Mohammad Al-Houqani^1,10  Ayesha S. Al Dhaheri^1,11  Eiman AlZaabi^1,12  Abdulla AlJunaibi^1,13  Scott Scherman^1,14  Omar El-Shahawy^1,14  Mai Aljaber^1,15  E. Murat Tuzcu^1,16  Wael Almahmeed^1,16  Rami H. Al-Rifai^1,17  Syed M. Shah^1,17  Fatma Al-Maskari^1,18  Luai A. Ahmed^1,18  Laila Abdel Wareth^1,19  Andrea Leinberger-Jabari^2,20  Amar Ahmad^2,20  Youssef Idaghdour^2,20  Fatima Mezhal^2,20  Abdishakur Abdulle^2,20  Raghib Ali^2,21  Fayza Alameri^2,22 

[1] Abu Dhabi Blood Bank Services, SEHA, Al-Ain, Abu Dhabi, UAE;Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, UAE;Department of Genetics and Molecular Biology, Khalifa University of Science and Technology, Abu Dhabi, UAE;Department of Biomedical Engineering, Khalifa University of Science and Technology, Abu Dhabi, UAE;College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE;College of Natural and Health Sciences, Zayed University, Abu Dhabi, UAE;Department of Cardiology, Zayed Military Hospital, Abu Dhabi, UAE;Department of Environmental Medicine, New York University of Medicine, New York, USA;Department of Epidemiology and Public Health, College of Medicine and Health Sciences, Khalifa University of Sciences and Technology, Abu Dhabi, UAE;Department of Health Science, Higher Colleges of Technology, Abu Dhabi, UAE;Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE;Department of Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE;Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE;Department of Pathology, Sheikh Shakhbout Medical City, Abu Dhabi, UAE;Department of Pediatrics, Zayed Military Hospital, Abu Dhabi, UAE;Department of Population Health, New York University School of Medicine, New York, USA;Healthpoint Hospital, Abu Dhabi, UAE;Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE;Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE;Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE;Zayed Center for Health Sciences, United Arab Emirates University, Al-Ain, UAE;Pathology and Laboratory Medicine Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE;Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE;Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE;MRC Epidemiology Unit, University of Cambridge, Cambridge, UK;Zayed Military Hospital, Abu Dhabi, UAE;

关键词: Cardiovascular disease;    Cardiometabolic risk factors;    Obesity;    Dysglycemia;    Dyslipidemia;    Hypertension;    Central obesity;    Metabolic Syndrome;   

DOI  :  10.1186/s13098-021-00758-w

来源: Springer

【 摘 要 】

IntroductionSimilar to other non-communicable diseases (NCDs), people who develop cardiovascular disease (CVD) typically have more than one risk factor. The clustering of cardiovascular risk factors begins in youth, early adulthood, and middle age. The presence of multiple risk factors simultaneously has been shown to increase the risk for atherosclerosis development in young and middle-aged adults and risk of CVD in middle age.ObjectiveThis study aimed to address the interrelationship of CVD risk factors and their accumulation in a large sample of young adults in the United Arab Emirates (UAE).MethodsBaseline data was drawn from the UAE Healthy Future Study (UAEHFS), a volunteer-based multicenter study that recruits Emirati nationals. Data of participants aged 18 to 40 years was used for cross-sectional analysis. Demographic and health information was collected through self-reported questionnaires. Anthropometric data and blood pressure were measured, and blood samples were collected.ResultsA total of 5126 participants were included in the analysis. Comorbidity analyses showed that dyslipidemia and obesity co-existed with other cardiometabolic risk factors (CRFs) more than 70% and 50% of the time, respectively. Multivariate logistic regression analysis of the risk factors with age and gender showed that all risk factors were highly associated with each other. The strongest relationship was found with obesity; it was associated with four-fold increase in the odds of having central obesity [adjusted OR 4.70 (95% CI (4.04–5.46)], and almost three-fold increase odds of having abnormal glycemic status [AOR 2.98 (95% (CI 2.49–3.55))], hypertension (AOR 3.03 (95% CI (2.61–3.52))] and dyslipidemia [AOR 2.71 (95% CI (2.32–3.15)]. Forty percent of the population accumulated more than 2 risk factors, and the burden increased with age.ConclusionIn this young population, cardiometabolic risk factors are highly prevalent and are associated with each other, therefore creating a heavy burden of risk factors. This forecasts an increase in the burden of CVD in the UAE. The robust longitudinal design of the UAEHFS will enable researchers to understand how risk factors cluster before disease develops. This knowledge will offer a novel approach to design group-specific preventive measures for CVD development.

【 授权许可】

CC BY