Bio-distribution of Carbon Nanoparticles Studied by Photoacoustic Measurements

Nanoscale Research Letters

Research

Tatiana Borisova¹  Vladimir Lysenko²  Konstantin Paliienko³  Natalia Krisanova³  Kateryna Dubyk⁴  Valeriy Skryshevsky⁴  Sergei Alekseev⁴  Alain Geloen⁵  Mykola Isaiev⁶ 

[1] Corporation Science Park, Taras Shevchenko University of Kyiv, 60, Volodymyrska Street, 01033, Kyiv, Ukraine;Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovicha Street, 01054, Kiev, Ukraine;Light Matter Institute, UMR-5306, Claude Bernard University of Lyon/CNRS, Université de Lyon, 69622, Villeurbanne Cedex, France;Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovicha Street, 01054, Kiev, Ukraine;Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska Street, 01601, Kyiv, Ukraine;Corporation Science Park, Taras Shevchenko University of Kyiv, 60, Volodymyrska Street, 01033, Kyiv, Ukraine;UMR Ecologie Microbienne Lyon (LEM), CNRS 5557, INRAE 1418, Claude Bernard University of Lyon, VetAgro Sup, Research Team “Bacterial Opportunistic Pathogens and Environment” (BPOE), University of Lyon, 69622, Villeurbanne, France;Université de Lorraine, CNRS, LEMTA, F-54000, Nancy, France;

关键词: Photoacoustics;    Contrast agents for photoacoustic tomography;    Carbon nanodots;    Carbon flurooxide nanoparticles;    Intravenous injection;    Autological biocorona;    Rats;   

DOI  :  10.1186/s11671-022-03768-3

 received in 2022-09-18, accepted in 2022-12-13,  发布年份 2022

来源: Springer

【 摘 要 】

Carbon-based nanomaterials are promising for a wide range of biomedical applications, i.e. drug delivery, therapy, and imaging including photoacoustic tomography, where they can serve as contrast agents, biocompatibility and biodistribution of which should be assessed before clinical setting. In this paper, localization of carbon flurooxide nanoparticles, carbon nanodots from β-alanine, carbon nanodots from urea and citric acid and glucose-ethylenediamine nanoparticles (NPs) in organs of Wistar rats were studied by photoacoustic measurements after 24 h of their intravenous injection. 16 ns light pulse from a Q-switched Nd:YAG laser with 1064 nm wavelength was used as an excitation source. The laser-induced photoacoustic signals were recorded with a ring piezoelectric detector. Light absorption by carbon NPs resulted in noticeable enhancement of the photoacoustic amplitude in the tissues where the NPs were accumulated. The NPs were preferably accumulated in liver, kidneys and spleen, and to a lesser extent in heart and gastrocnemius muscles. Together with remarkable fluorescent properties of the studied carbon nanomaterials, their photoacoustic responses allow their application for bi-modal fluorescence-photoacoustic bio-imaging.

【 授权许可】

CC BY   
© The Author(s) 2022

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Fig. 10

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