Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection

BMC Research Notes

Research Note

Euijin Chang¹  Pyoeng Gyun Choe¹  Nam Joong Kim¹  Young Hoon Hwang¹  Seungjae Lee¹  Chan Mi Lee¹  Yunsang Choi¹  Donghwan Kim¹  Hyeon Jae Jo¹  Dohyeon Park¹  Sang-Min Oh²  Eunyoung Lee³  Jee-Soo Lee⁴  Taek Soo Kim⁴  Moon-Woo Seong⁴ 

[1] Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, 03080, Seoul, Republic of Korea;Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, 03080, Seoul, Republic of Korea;Department of Internal Medicine, Jeonbuk National University Medical School and Hospital, 20 Geonjiro, Deokjin-gu, 54907, Jeonju, Jeollabuk-do, Republic of Korea;Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, 03080, Seoul, Republic of Korea;Division of Infectious Diseases, Seoul Metropolitan Government – Seoul National University Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, 07061, Seoul, Republic of Korea;Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, 03080, Seoul, Republic of Korea;

关键词: COVID-19;    SARS-CoV-2;    RT-PCR;    Saliva;    Antigen;   

DOI  :  10.1186/s13104-022-06226-6

 received in 2022-04-22, accepted in 2022-10-10,  发布年份 2022

来源: Springer

【 摘 要 】

ObjectiveWe evaluated the sensitivity and specificity of the Panbio™ COVID-19 Ag rapid test device using nasal swabs and those of the SSf-COVID19 kit, one of RT-PCR tests, using saliva specimens. These tests were compared with RT-PCR tests using nasopharyngeal swabs for the diagnosis of SARS-CoV-2 infection. The three diagnostic tests were simultaneously conducted for patients aged ≥ 18 years, who were about to be hospitalized or had been admitted for COVID-19 confirmed by RT-PCR in two research hospitals from August 20 to October 29, 2021. Nasal swabs were tested using the Panbio™ COVID-19 Ag rapid test device. More than 1 mL of saliva was self-collected and tested using the SSf-COVID19 kit.ResultsIn total, 157 patients were investigated; 124 patients who were about to be hospitalized and 33 patients already admitted for COVID-19. The overall sensitivity and specificity of the Panbio™ COVID-19 Ag rapid test device with nasal swabs were 64.7% (95% confidence interval [CI] 47.9–78.5%) and 100.0% (95% CI 97.0–100.0%), respectively. The median time to confirm a positive result was 180 s (interquartile range 60–255 s). The overall sensitivity and specificity of the SSf-COVID19 kit with saliva specimens were 94.1% (95% CI 80.9–98.4%) and 100.0% (95% CI 97.0–100.0%), respectively.

【 授权许可】

CC BY   
© The Author(s) 2022