Oral manifestations of COVID-19 in unvaccinated patients: a cross-sectional study

BMC Oral Health

Research

Ezequias Batista Martins¹  Patrícia Brasil¹  Guilherme Amaral Calvet¹  Tatiana Jorge Fernandes²  Marilda Agudo Mendonça Teixeira de Siqueira³  Maria Ogrzewalska³ 

[1]Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

[2]Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

[3]Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases - Oswaldo Cruz Foundation, Av. Brasil, 4365, 21045-900, Rio de Janeiro, Manguinhos, Brazil

[4]Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil

[5]SARS-CoV National Reference Laboratory for the Brazilian Ministry of Health (MoH) and Regional Reference Laboratory in Americas for the Pan-American Health Organization, Washington, USA

关键词: SARS-CoV-2;    COVID-19;    Saliva;    Oral manifestations;    Oral cavity;    Xerostomia;   

DOI  :  10.1186/s12903-023-03325-z

 received in 2023-05-22, accepted in 2023-08-17,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEarly studies have highlighted the possible development of dysgeusia and anosmia in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and these manifestations should be considered a potential indication of coronavirus disease 19 (COVID-19). As potential contributors to these symptoms, dentists should perform careful oral and oropharyngeal examinations and document suspicious oral lesions in patients with COVID-19, especially in those who complain of loss of taste and smell. The study’s objective was to assess the prevalence of oral manifestations among ambulatory unvaccinated symptomatic patients with suspected COVID-19 during the acute phase of the disease.MethodsThis cross-sectional study evaluated oral manifestations in adults (aged ≥ 18 years) with suspected and confirmed SARS-CoV-2 infection. Chi-square and Fisher’s exact tests were used to compare data between the groups (rRT-PCR-positive and rRT-PCR-negative patients).ResultsOne hundred thirty-six participants were included. Most were female (n = 79; 58.1%), with a mean age of 39.53 (± 14.17) years. Of these, 54 (39.7%) had a positive rRT-PCR test, and 82 (60.3%) had negative rRT-PCR results. Oral manifestations were observed in 40 participants (74.1%) in the rRT-PCR-positive group and 67 participants (81.7%) in the rRT-PCR-negative group. The most common oral manifestations were xerostomia (n = 85; 62.5%) and dysgeusia/ageusia (n = 57; 41.9%). Different rates of gingivitis (n = 12; 22.2% vs. n = 5; 6.1%; p = 0.005) and halitosis (n = 7; 13.0% vs. n = 1; 1.2%; p = 0.007) were observed between the rRT-PCR-positive and -negative groups, respectively. Mouth ulcers, glossitis, tongue coating, and petechiae were reported in both groups without significant differences.ConclusionsA high prevalence of oral manifestations was observed in symptomatic patients with suspected or confirmed COVID-19.Clinical RelevanceThis study highlights the importance of routine oral examinations by dentists as part of the multidisciplinary care of COVID-19 patients.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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