Non-motor manifestation of Parkinson's disease: a cross-sectional study in a teaching hospital in Jordan

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Research

Said Salah Dahbour¹  Mohammad J. Al Murr¹  Nada T. Al Antary¹  Maram Mohsen¹  Liyan H. Oweis¹  Safa Al Fegi¹ 

[1] Neurology Division, Department of Internal Medicine, Faculty of Medicine, The University of Jordan, Jordan University Hospital, PO Box 13046, Queen Rania Al Abdullah Street, Al Jabaiha Area, 11942, Amman, Capital Governorate, Jordan;

关键词: Parkinson's disease;    Non-motor manifestations;    Pathogenesis;    Pathophysiology;    Jordan;   

DOI  :  10.1186/s41983-022-00559-6

 received in 2021-11-28, accepted in 2022-10-01,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundParkinson's disease (PD) is the most common degenerative movement disorder. It is featured by motor manifestations and up till now the clinical diagnosis is based on them. Since the progress in the symptomatic treatment of PD and the longer survival of patients, non-motor manifestations (NMM) were more recognized and considered to be significant. The importance of NMM is that they reflect the more diffuse pathology of PD and may represent an opportunity of earlier diagnosis and treatment. Here in this cross-sectional study, we try to estimate the frequency of such manifestations in PD patients in the country. Using slightly modified PD non-motor (28 of 30 responses) questionnaire (NMS Quest), we studied the incidence of NMM in 100 PD patients attending one major teaching hospital and compared their occurrence in 130 age- and gender-matched non-PD controls.ResultsOut of 100 PD patients (40% females) mean age 67.4 ± 12 with disease duration of 7.3 ± 5.8, range < 1–33.2 years), and 130 control subjects (48.5% females), mean age 65.0 ± 7.0. PD patients had 8.6 ± 5.3 NMM while controls had 3.4 ± 3.3 NMM, respectively (p < 0.00001 t test). Constipation, urgency, insomnia, sad feeling, panic, light headedness and recent memory impairment were the most prevalent NMM in PD compared to controls, while nocturia, restless legs, encopresis and falling were not different in the two groups. The number of NMM ranged from 0 to 21 in PD patients with 50% having ≥ 8 manifestations. The number of NMM did not correlate with age, gender, or disease duration as defined by the classical motor symptoms. Frequency of 23 of these 28 manifestations differed significantly in PD patients compared to controls.ConclusionsThis study confirms that NMM in Jordanian PD patients are very common as reported in other populations. This signifies the universal prevalence of such NMM reflecting their important impact on their daily life and their relevant contribution to better understanding of this disease.

【 授权许可】

CC BY   
© The Author(s) 2022

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