BMC Pregnancy and Childbirth | |
CD97 expression level and its effect on cell adhesion in Preeclampsia | |
Research | |
Semih Tan1  Hulya Cetin1  Saim Ozdamar1  Ayhan Atigan2  Omer Tolga Guler3  Yeliz Arman Karakaya4  | |
[1] Department of Histology and Embryology, Faculty of Medicine, Pamukkale University, Denizli, Turkey;Department of Obstetrics and Gynecology, Faculty of Medicine, Karabuk University, School of Medicine, Karabuk, Turkey;Department of Obstetrics and Gynecology, Faculty of Medicine, Pamukkale University, Denizli, Turkey;Department of Pathology, Faculty of Medicine, Pamukkale University, Denizli, Turkey; | |
关键词: Preeclampsia; Cadherins; CD97; E-cadherin; N-cadherin; Integrin beta-4; | |
DOI : 10.1186/s12884-022-05280-z | |
received in 2022-09-16, accepted in 2022-12-02, 发布年份 2022 | |
来源: Springer | |
【 摘 要 】
ObjectivesCellular interactions and cell adhesion underlie preeclampsia (PE). The aim of the current study is to investigate the role of cell adhesion molecules such as CD97, neural (N)-cadherin, epithelial (E) -cadherin and integrin beta-4 in PE.MethodsThis prospective study included 20 pregnant women with PE and a control group of 16 healthy pregnant women who were matched for age, gestational age, gravida and parity. Standard blood tests and placental cell adhesion molecule immunohistochemical staining were examined.ResultsThe creatinine, uric acid and lactate dehydrogenase (LDH) levels from standard blood tests were found to be statistically higher in the PE group (p = 0.002, p = 0.000, p = 0.001; respectively). In the PE group, the CD97 maternal serum level was statistically significantly lower, as was its immunohistochemical expression in placental sections (p = 0.028, p = 0.000; respectively). The E-cadherin expression score was statistically higher in the PE group compared to the control group (3,65 ± 1,84 vs 2,06 ± 1,76 respectively; p = 0.003). The N-cadherin expression score was statistically lower in the PE group compared to the control group (1,50 ± 0,82 vs 2,43 ± 1,59 respectively; p = 0.049). Integrin beta-4 was not statistically different between groups.ConclusionsCellular interaction may be responsible for PE as in cancer. A balance in intercellular communication, as researched in cancer therapy, may offer the solution in PE.
【 授权许可】
CC BY
© The Author(s) 2022
【 预 览 】
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RO202305061404248ZK.pdf | 1418KB | download | |
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