Vagus nerve stimulation and inflammation: expanding the scope beyond cytokines

Bioelectronic Medicine

Editorial

Aidan Falvey¹ 

[1] Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, 11030, Manhasset, NY, USA;

关键词: Cytokines;    Inflammation;    Inflammatory reflex;    Neutrophils;    Resolution;    Specialized pro-resolving mediators;    Vagus nerve stimulation;   

DOI  :  10.1186/s42234-022-00100-3

来源: Springer

【 摘 要 】

Approximately 20 years ago it was discovered that the vagus nerve regulates pro-inflammatory cytokine levels and inflammation. Subsequent research using several preclinical models revealed that vagus nerve stimulation evokes a protective decrease in pro-inflammatory cytokines in multiple inflammatory disorders. Consequently, the pro- and anti- inflammatory cytokine balance has become the predominant readout for indicating a positive outcome of vagus nerve stimulation. However, cytokine levels are just a single aspect of an effective immune response. It is conceivable that vagus nerve stimulation regulates inflammation through additional mechanisms. In this letter, I discuss a manuscript that describes how vagus nerve stimulation promotes resolution of inflammation via regulating the balance of specialised pro-resolving mediator levels and neutrophil activity.

【 授权许可】

CC BY   
© The Author(s) 2022