Cancer Nanotechnology | 卷:14 |
Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumor | |
Research | |
Sheng-Tao Yang1  Xian Wu1  Kexin Tang2  Xiaohai Tang2  Cheng Zeng2  Yuanfang Huang2  Ping Xie3  | |
[1] Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, 610041, Chengdu, People’s Republic of China; | |
[2] Sichuan Enray Pharmaceutical Sciences Company, Chengdu, People’s Republic of China; | |
[3] State Key Laboratory of Oral Diseases, West China, College of Stomatology, Sichuan University, Chengdu, People’s Republic of China; | |
关键词: Carbon nanoparticles; Ferrous iron; Antitumor activity; Ferroptosis; Magnetic resonance imaging; | |
DOI : 10.1186/s12645-023-00196-5 | |
received in 2023-02-24, accepted in 2023-04-11, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
BackgroundOverwhelming Fe accumulation in tumor arouses strong oxidative stress. To benefit the cancer patients, Fe(II) delivered by carbon nanoparticles-Fe(II) complex (CNSI-Fe) should be visualized to ensure the successful intratumoral injection and the antitumor mechanisms should be investigated at molecular level.ResultsIntracellular Fe accumulations associating with the uptakes of CNSI-Fe were observed both in vitro and in vivo. The retention of Fe(II) in tumor over 72 h was visualized by magnetic resonance imaging. CNSI-Fe inhibited the tumor growth and expanded the lifespan of colonic tumor-bearing mice. The antitumor activity of CNSI-Fe was attributed to the increases of OH radicals and the oxidative stress in tumor cells, which resulted in cell apoptosis and ferroptosis. The transcriptome analyses confirmed the changes of ferroptosis and inflammation signaling pathways by CNSI-Fe treatment. The low toxicity of CNSI-Fe was indicated by the serum biochemistry, hematology, and histopathology.ConclusionCNSI-Fe induced the efficient apoptosis and ferroptosis of colonic tumor for cancer therapy. Our results would benefit the clinical applications of CNSI-Fe and stimulate great interest in the nanomedicine.
【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
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