Imaging characterization of an adult H3 K27M-altered diffuse midline glioma of the medulla oblongata with a confounding steroid response

Radiology Case Reports

article

Claudia Godi¹  Paolo Garofalo¹  Marcella Callea¹  Paolo Vezzulli¹  Maurizio Barbera¹  Carlo Mandelli¹  Elena Mazza¹  Bianca Pollo¹  Maria Rosa Terreni¹  Antonella Castellano¹  Nicoletta Anzalone¹  Andrea Falini¹ 

[1] Neuroradiology Unit and CERMAC, IRCCS San Raffaele Scientific Institute

关键词: Diffuse midline glioma;    High-grade glioma;    Medulla;    Steroid response;    Magnetic resonance imaging;   

DOI  :  10.1016/j.radcr.2022.10.082

学科分类：生物化学工程

来源: University of Washington * Department of Radiology

【 摘 要 】

We report an uncommon, infratentorial localization of adult H3 K27M-altered diffuse midline glioma arising in a particularly rare site (medulla oblongata). In addition to this unusual presentation, the lesion exhibited a substantial contrast enhancement and size decrease after dexamethasone, generating diagnostic dilemmas. Histology, molecular details, advanced Magnetic Resonance imaging features and differential diagnoses are here described and discussed, as well as common misconceptions about steroid-sensitive mass lesions, and practical difficulties for clinicians involved in the process of making diagnosis.

【 授权许可】

CC BY|CC BY-NC-ND