MRI comparative study of diffuse midline glioma, H3 K27-altered and glioma in the midline without H3 K27-altered

BMC Neurology

Research

Hong-zhang Xu¹  Ying-jie Yue²  Chun-xiao Cui²  Song Gao²  Ji-ping Zhao²  Xue-jun Liu²  Hao-zhi Lin³ 

[1] Department of Radiology, Shidao People’s Hospital, Rongcheng, China;Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China;Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, China;

关键词: Diffuse midline glioma;    Magnetic resonance imaging;    H3 K27-altered;   

DOI  :  10.1186/s12883-022-03026-0

 received in 2022-03-23, accepted in 2022-12-13,  发布年份 2022

来源: Springer

【 摘 要 】

PurposeThe MRI features of Diffuse midline glioma, H3 K27-altered and glioma in the midline without H3 K27-altered were compared and analyzed, and the changes in the apparent diffusion coefficient (ADC) of the two groups were quantitatively analyzed.MethodsThe MRI images of 35 patients with Diffuse midline gliomas, H3 K27-altered and gliomas in the midline without H3 K27-altered were analyzed retrospectively. The location, edge, signal, peritumoral edema and enhancement characteristics of the lesions were observed, and the changes in ADC values were analyzed.ResultsIn the H3 K27-altered group, 85.7% (12/14) of the tumors were located in the thalamus and brainstem compared with 28.6% (6/21) in the no H3 K27-altered group. In the H3 K27-altered group, for tumors only located in the midline area, only 14.3% (1/7) had irregular shapes and unclear boundaries, while for tumors also invaded the extramidline tissues 85.7% (6/7) had irregular shapes and unclear boundaries.The"basilar artery wrapped sign” was found in 6 patients with tumors located in the pons in the H3 K27-altered group, but none in the no H3 K27-altered group had this sign. In the H3 K27-altered group, only 14.3% (1/7) of the tumors confined to the midline area had small cystic degeneration and necrosis, while for tumors also invaded the extramidline tissues, 100% (7/7) of the tumors had cystic degeneration and necrosis, and the cystic degeneration and necrosis only located in the extramidline region of the tumor in 6 cases.A total of 78.6% (11/14) of tumors in the H3 K27-altered group showed mild to moderate enhancement, while 47.6% (10/21) of tumors in the no H3 K27-altered group showed mild to moderate enhancement. The average peritumoral edema index was 1.13 in the H3 K27-altered group and 1.75 in the no H3 K27-altered group. The average ADC value of tumor in the H3 K27-altered group was 7.83 × 10− 4 mm2/s, and the ratio to normal brain tissue was 0.844, while the values in the no H3 K27-altered group were 13.5 × 10− 4 mm2/s and 1.75, respectively.ConclusionCompared with gliomas in the midline without H3 K27-altered, The MRI findings and ADC value of Diffuse midline gliomas, H3K27-altered have some characteristics, which can help improve the diagnosis and differential diagnosis.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 5

Fig. 5

Fig. 5

Fig. 3

Fig. 1