A curious case of T2-FLAIR mismatch in H3K27M mutant glioma

Radiology Case Reports

article

William L. Valentino¹  Darren Okada¹  Shiv Bhanu¹ 

[1] Riverside Community Hospital

关键词: T2-FLAIR mismatch;    Adult brainstem glioma;    Diffuse midline glioma;    H3K27M mutation;    IDH mutation;    Astrocytoma;   

DOI  :  10.1016/j.radcr.2022.05.017

学科分类：生物化学工程

来源: University of Washington * Department of Radiology

【 摘 要 】

Diffuse midline gliomas are a rare relatively new classification of primary central nervous system tumors which include astrocytomas , oligodendrogliomas , and glioblastomas . The T2-FLAIR mismatch sign is regarded as a highly specific imaging feature of IDH-mutant, 1p/19q non-codeleted astrocytomas. The case presented herein demonstrates this sign, however, in a non-IDH mutated diffuse midline glioma with a H3K27M mutation, a World Health Organization Grade IV neoplasm. Although preoperative diagnosis can provide important treatment and prognostic information, it is often quite difficult particularly in primary central nervous system tumors.

【 授权许可】

CC BY|CC BY-NC-ND