The morphokinetics algorithm based on data from day 5 blastocyst transfer (KIDScoreD5 version 3) is also useful for embryo selection in day 6 blastocyst transfer

Reproductive medicine and biology

article

Masashi Shioya¹  Tatsuya Kobayashi¹  Tomoharu Sugiura¹  Maki Fujita¹  Keiichi Takahashi¹ 

[1] Takahashi Women's Clinic;Department of Reproductive Medicine, Graduate School of Medicine, Chiba University

关键词: blastocyst;    embryo development;    pregnancy outcome;    single embryo transfer;    time-lapse imaging;   

DOI  :  10.1002/rmb2.12484

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose To analyze whether the morphokinetics algorithm based on data from day 5 blastocyst transfer (KIDScoreD5 version 3) can predict the pregnancy rate of both day 5 and day 6 blastocyst transfers. Methods The relationship between KIDScoreD5 and clinical pregnancy rate was evaluated using the Cochran–Armitage test and receiver-operating characteristic (ROC) curve analysis. Results A positive correlation was observed between the KIDScoreD5 value and clinical pregnancy rate for both day 5 ( p  = 0.0003) and day 6 blastocysts ( p  = 0.0019) using the Cochrane–Armitage test. ROC curve analysis showed that the area under the curve (AUC) of KIDScoreD5 for clinical pregnancy was 0.627 (0.575–0.677, p  < 0.0001) for day 5 blastocysts and 0.685 (0.571–0.780, p  = 0.0009) for day 6 blastocysts. The combined analysis of both day 5 and day 6 blastocysts also showed an AUC of 0.680 (0.636–0.720, p  < 0.0001), suggesting that it is possible to select embryos that are more likely to result in pregnancy. Conclusions KIDScoreD5 could predict pregnancy not only in day 5 blastocysts but also in day 6 blastocysts. When both day 5 and day 6 blastocysts are vitrified, embryo selection by KIDScoreD5 is possible with a high prediction ability of pregnancy.

【 授权许可】

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