Single fresh and frozen-thawed blastocyst transfer using hyaluronan-rich transfer medium

REPRODUCTIVE BIOMEDICINE ONLINE

卷:15

Article

Korosec, Sara ; Virant-Klun, Irma ; Tomazevic, Tomaz ; Zech, Nicolas H. ; Meden-Vrtovec, Helena

关键词: blastocyst;    hyaluronan;    single blastocyst transfer;    single embryo transfer;   

DOI  :  10.1016/S1472-6483(10)60538-X

来源: Elsevier

【 摘 要 】

The purpose of this prospective randomized study was to evaluate use of a hyaluronan-rich transfer medium in fresh and frozen-thawed single blastocyst transfer. The study included 279 single blastocyst transfers in women aged <37 years in their first, second or third treatment cycle. According to the type of single blastocyst transfer (fresh elective or frozen-thawed) the women were divided into two study and two control groups. In both study groups (n = 130) transfers were performed using hyaluronan and in the control groups (n = 149) a conventional transfer medium was used. The results indicate that fresh elective single blastocyst transfer with hyaluronan results in significantly higher pregnancy rates in a selected subgroup of women; those with >= 2 blastocysts developed to day 5 and a previous implantation failure (55% versus 10%; P = 0.012). Overall pregnancy rates after fresh elective and frozen-thawed single blastocyst transfer were similar in both study and control groups.

【 授权许可】

Free