Is the birthweight of singletons born after IVF reduced by ovarian stimulation or by IVF laboratory procedures?

REPRODUCTIVE BIOMEDICINE ONLINE

卷:21

Article

Pelinck, M. J.¹  Hadders-Algra, M.²  Haadsma, M. L.¹  Nijhuis, W. L.²  Kiewiet, S. M.²  Hoek, A.¹  Heineman, M. J.^1,3  Middleburg, K. J.² 

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynaecol, Sect Reprod Med, NL-9713 AV Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Sect Dev Neurol, NL-9713 AV Groningen, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Obstet & Gynaecol, NL-1105 AZ Amsterdam, Netherlands

关键词: IVF;    natural cycle;    ovarian stimulation;    perinatal outcome;    pregnancy outcome;    single embryo transfer;   

DOI  :  10.1016/j.rbmo.2010.04.024

来源: Elsevier

【 摘 要 】

Singletons born after IVF are at risk of adverse pregnancy outcome, the cause of which is unknown. The present study investigated the influence of ovarian stimulation and IVF laboratory procedure on birthweight. Birthweight of singleton pregnancies resulting from IVF treatment with (n = 161) and without ovarian stimulation (using a modified natural cycle (MNC) protocol; n = 158), and spontaneous conceptions in subfertile patients (n = 132) were compared. Mean +/- SD birthweight of singletons after conventional IVF with ovarian stimulation, MNC-IVF and natural conception were 3271 +/- 655, 3472 +/- 548 and 3527 +/- 582 g (P = 0.001). After adjustment for biological and social confounders, the difference in birthweight between conventional IVF and MNC-IVF was reduced to 88 g and the differences between conventional IVF and MNC-IVF versus spontaneous conceptions to 123 and 23 g, respectively. The results lead to three conclusions. First, a major part of the crude differences in birthweight between the three groups is related to patient and pregnancy characteristics. Second, the IVF laboratory procedure has no influence on birthweight. Third, although a trend towards lower birthweight after ovarian stimulation was found, an adverse effect of ovarian stimulation on birthweight was not substantiated. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free