Associations Between DNA Methylation Age Acceleration, Depressive Symptoms, and Cardiometabolic Traits in African American Mothers From the InterGEN Study

Epigenetics Insights

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Nicole Beaulieu Perez¹  Allison A Vorderstrasse²  Gary Yu¹  Gail D’Eramo Melkus¹  Fay Wright¹  Stephen D Ginsberg³  Cindy A Crusto⁵  Yan V Sun⁷  Jacquelyn Y Taylor⁹ 

[1] Rory Meyers College of Nursing, New York University;College of Nursing, University of Massachusetts Amherst;Center for Dementia Research, Nathan Kline Institute;NYU Grossman School of Medicine;Yale School of Medicine;Department of Psychology, University of Pretoria;Emory University School of Public Health;Atlanta VA Health Care System;Columbia University School of Nursing

关键词: Depressive symptoms;    DNA methylation;    African American women;    accelerated aging;    chronic medical conditions;   

DOI  :  10.1177/25168657221109781

学科分类：兽医学

来源: Tu Delft Transport Institute

【 摘 要 】

Background: African American women (AAW) have a high risk of both cardiometabolic (CM) illness and depressive symptoms. Depressive symptoms co-occur in individuals with CM illness at higher rates than the general population, and accelerated aging may explain this. In this secondary analysis, we examined associations between age acceleration; depressive symptoms; and CM traits (hypertension, diabetes mellitus [DM], and obesity) in a cohort of AAW.

【 授权许可】

CC BY|CC BY-NC