Determinants of accelerated metabolomic and epigenetic aging in a UK cohort

Aging Cell

Mika Ala-Korpela¹  Paul Elliott²  Oliver Robinson²  Rui Climaco Pinto²  Evangelos Handakas²  Andy Heard²  Ibrahim Karaman²  Matthias Wielscher²  He Gao²  Ioanna Tzoulaki²  Marc Chadeau Hyam²  Marjo‐Riitta Jarvelin³  Raha Pazoki⁴  Paolo Vineis⁵  Silvia Polidoro⁵  Giovanni Fiorito⁶  Matthew Lewis⁷ 

[1]Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland

[2]NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

[3]MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

[4]MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

[5]Center for Life Course Health Research, Faculty of Medicine, University of Oulu and Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland

[6]Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK

[7]MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

[8]Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK

[9]MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

[10]Italian Institute for Genomic Medicine (IIGM, former HuGeF), Candiolo, Italy

[11]MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

[12]Laboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari, Sassari, Italy

[13]Italian Institute for Genomic Medicine (IIGM, former HuGeF), Candiolo, Italy

[14]National Phenome Centre, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

关键词: accelerated aging;    affective mood disorders;    DNA methylation;    metabolomics;    molecular biology of aging;    risk factors;   

DOI  :  10.1111/acel.13149

来源: Wiley

【 授权许可】

CC BY