Adipose-Derived Cells

Cell Transplantation

Review

Brian M. Strem¹  Patrick W. Serruys²  H. J. Duckers²  Emanuele Meliga² 

[1] Cytori Therapeutics, Inc., San Diego, CA 92121, USA;Thoraxcenter, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands;

关键词: Cardiac regeneration;    Adipose-derived stem cells;    Heart failure;    Acute myocardial infarction;   

DOI  :  10.3727/096368907783338190

来源: Sage Journals

【 摘 要 】

Heart failure is by far the most common cause of hospitalization in Western countries, with onerous economic consequences. Cell therapy holds great promise for use in tissue regeneration and is increasingly used in an effort to improve outcomes in cardiac disease. Recently it has been shown that adipose tissue, in addition to committed adipogenic, endothelial progenitor cells and pluripotent vascular progenitor cells, also contains multipotent cell types (adipose-derived stem cells, ADSCs) that, in cell culture conditions, have shown to have an impressive developmental plasticity including the ability to undergo multilineage differentiation and self-renewal. ADSCs express multiple CD marker antigens similar to those observed on MSCs and are also capable of secreting a large number of angiogenesis-related cytokines, including vascular endothelial growth factor, granulocyte/macrophage colony stimulating factor, stromal-derived factor-1α, and hepatocyte growth factor. Adipose tissue can be harvested in large quantities with minimal morbidity in several regions of the body and, on average, 100 ml of human adipose tissue yields about 1 × 106 stem cells. Studies conducted in porcine AMI models have shown a significant LV functional improvement, with no report of any potentially fatal arrhythmias. The APOLLO trial, a prospective, double blind, randomized, placebo-controlled trial currently in the recruiting phase, is a “first-in-man” study that explores the safety and feasibility of ADSC transplantation in patients with acute MI.

【 授权许可】

Unknown   
© 2007 Cognizant Comm. Corp.