PARIS and SPARTA: Finding the Achilles’ Heel of SARS-CoV-2

mSphere

Aubree Gordon¹  Hannah B. Hanley²  David Forgacs²  Florian Krammer²  Elaine F. Reed³  Riccardo Valdez⁴  David Manthei⁴  Jeremie H. Estepp⁵  Ted M. Ross⁵  Stacey Schultz-Cherry⁵  Aditya H. Gaur⁵  Joshua Wolf⁵  Michael R. Yeaman⁶  Joanna Schaenman⁶  Loren G. Miller⁶  Vamsi Kota⁷  Suresh Pallikkuth⁸  Savita Pahwa⁸  Viviana Simon⁹  Frans Cuevas⁹  Komal Srivastava⁹  Juan Manuel Carreño⁹  Ali H. Ellebedy^1,10  Ravindra Kolhe^1,11  Paul G. Thomas^1,12  Sarah Cobey^1,13  Ryan F. Bloomquist^1,14 

[1] Immunology, Washington University School of Medicine, St. Louis, Missouri, USA;Center for Vaccine and Immunology, University of Georgia, Athens, Georgia, USA;Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA;Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA;Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, Tennessee, USA;Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA;Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA;Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA;Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA;;Department of Pathology &Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA;Department of Pathology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA;Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA;Department of Restorative Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia, USA;

关键词: COVID-19;    SARS-CoV-2;    antibodies;    cohort study;    reinfection;   

DOI  :  10.1128/msphere.00179-22

来源: DOAJ

【 摘 要 】

ABSTRACT To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. IMPORTANCE Determining reinfection rates and correlates of protection against SARS-CoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.

【 授权许可】

Unknown