PICK-ing Malaysia’s Epidemic Apart: Effectiveness of a Diverse COVID-19 Vaccine Portfolio

Vaccines

Thevesh Thevananthan¹  Boon Hwa Tng¹  Jing Lian Suah¹  Hazlina Yahaya²  Maheshwara Rao Appannan²  Norhayati Rusli²  Sheamini Sivasampu³  Peter Seah Keng Tok³  Masliyana Husin³  Kalaiarasu M. Peariasamy³  Su Miin Ong³  Shahanizan Mohd Zin⁴  Mohd Fikri Ujang⁴  Faizah Muhamad Zin⁴  Hishamshah Mohd Ibrahim⁵  Noor Hisham Abdullah⁵ 

[1] COVID-19 Immunisation Task Force, Government of Malaysia, Putrajaya 62000, Malaysia;Disease Control Division, Ministry of Health Malaysia, Putrajaya 62590, Malaysia;Institute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia;Medical Development Division, Ministry of Health Malaysia, Putrajaya 62590, Malaysia;Office of Director-General, Ministry of Health Malaysia, Putrajaya 62590, Malaysia;

关键词: COVID-19;    SARS-CoV-2;    COVID-19 vaccines;    vaccine effectiveness;    cohort study;    Malaysia;   

DOI  :  10.3390/vaccines9121381

来源: DOAJ

【 摘 要 】

Malaysia rolled out a diverse portfolio of predominantly three COVID-19 vaccines (AZD1222, BNT162b2, and CoronaVac) beginning 24 February 2021. We evaluated vaccine effectiveness with two methods, covering 1 April to 15 September 2021: (1) the screening method for COVID-19 (SARS-CoV-2) infection and symptomatic COVID-19; and (2) a retrospective cohort of confirmed COVID-19 cases for COVID-19 related ICU admission and death using logistic regression. The screening method estimated partial vaccination to be 48.8% effective (95% CI: 46.8, 50.7) against COVID-19 infection and 33.5% effective (95% CI: 31.6, 35.5) against symptomatic COVID-19. Full vaccination is estimated at 87.8% effective (95% CI: 85.8, 89.7) against COVID-19 infection and 85.4% effective (95% CI: 83.4, 87.3) against symptomatic COVID-19. Among the cohort of confirmed COVID-19 cases, partial vaccination with any of the three vaccines is estimated at 31.3% effective (95% CI: 28.5, 34.1) in preventing ICU admission, and 45.1% effective (95% CI: 42.6, 47.5) in preventing death. Full vaccination with any of the three vaccines is estimated at 79.1% effective (95% CI: 77.7, 80.4) in preventing ICU admission and 86.7% effective (95% CI: 85.7, 87.6) in preventing deaths. Our findings suggest that full vaccination with any of the three predominant vaccines (AZD1222, BNT162b2, and CoronaVac) in Malaysia has been highly effective in preventing COVID-19 infection, symptomatic COVID-19, COVID-19-related ICU admission, and death.

【 授权许可】

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