New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae)

International Journal of Molecular Sciences

Lee-Shing Fang¹  Jyh-Horng Sheu¹  Yu-Chia Chang²  Chun-Sung Sung²  Zhi-Hong Wen³  Yin-Di Su⁴  Yu-Hsin Chen⁴  Ping-Jyun Sung⁵  Yang-Chang Wu⁶  Jih-Jung Chen⁶ 

[1] Aquarium, Pingtung 944, Taiwan;Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan;Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan;;Department of Marine Biotechnology &;Department of Pharmacy &;National Museum of Marine Biology &

关键词: Briareum;    briarenolide;    briarane;    gorgonian;    anti-inflammatory;    iNOS;   

DOI  :  10.3390/ijms17010079

来源: DOAJ

【 摘 要 】

Six new 9-hydroxybriarane diterpenoids, briarenolides ZI–ZVI (1–6), were isolated from a gorgonian coral Briareum sp. The structures of briaranes 1–6 were elucidated by spectroscopic methods and by comparison of their spectroscopic data with those of related analogues. Briarenolides ZII (2) and ZVI (6) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.

【 授权许可】

Unknown