Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)

Marine Drugs

Tzu-Rong Su¹  Yin-Di Su²  Jyh-Horng Sheu²  Ping-Jyun Sung²  Zhi-Hong Wen²  Jih-Jung Chen³  Lee-Shing Fang⁴  Tsong-Long Hwang⁵  Yang-Chang Wu⁶ 

[1] Department of Beauty Science, Meiho University, Pingtung 912, Taiwan;Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center,National Sun Yat-sen University, Kaohsiung 804, Taiwan;Department of Pharmacy, Tajen University, Pingtung 907, Taiwan;Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan;

关键词: Briareum;    briarane;    octocoral;    anti-inflammatory;    iNOS;   

DOI  :  10.3390/md13021037

来源: DOAJ

【 摘 要 】

Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.

【 授权许可】

Unknown