Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)

Marine Drugs

Yin-Di Su¹  Tzu-Rong Su³  Zhi-Hong Wen¹  Tsong-Long Hwang²  Lee-Shing Fang⁵  Jih-Jung Chen⁴  Yang-Chang Wu⁶  Jyh-Horng Sheu¹  Ping-Jyun Sung¹ 

[1] Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;Department of Beauty Science, Meiho University, Pingtung 912, Taiwan; E-Mail:;Department of Pharmacy, Tajen University, Pingtung 907, Taiwan; E-Mail:;Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan; E-Mail:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:

关键词: Briareum;    briarane;    octocoral;    anti-inflammatory;    iNOS;   

DOI  :  10.3390/md13021037

来源: mdpi

【 摘 要 】

Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.