New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae)

International Journal of Molecular Sciences

Yin-Di Su²  Chun-Sung Sung¹  Zhi-Hong Wen²  Yu-Hsin Chen⁴  Yu-Chia Chang⁴  Jih-Jung Chen⁶  Lee-Shing Fang⁵  Yang-Chang Wu³  Jyh-Horng Sheu²  Ping-Jyun Sung² 

[1] Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan;Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan;;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, TaiwanNational Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan;Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan;Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan;

关键词: Briareum;    briarenolide;    briarane;    gorgonian;    anti-inflammatory;    iNOS;   

DOI  :  10.3390/ijms17010079

来源: mdpi

【 摘 要 】

Six new 9-hydroxybriarane diterpenoids, briarenolides ZI–ZVI (1–6), were isolated from a gorgonian coral Briareum sp. The structures of briaranes 1–6 were elucidated by spectroscopic methods and by comparison of their spectroscopic data with those of related analogues. Briarenolides ZII (2) and ZVI (6) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.