Briarenolides F and G, New Briarane Diterpenoids from a Briareum sp. Octocoral

Marine Drugs

Pei-Han Hong³  Yin-Di Su²  Jui-Hsin Su³  Yung-Husan Chen²  Tsong-Long Hwang⁵  Ching-Feng Weng³  Chia-Hung Lee³  Zhi-Hong Wen⁴  Jyh-Horng Sheu⁴  Nai-Cheng Lin²  Yueh-Hsiung Kuo¹ 

[1] Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan;Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan;Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;

关键词: briarenolide;    briarane;    Briareum;    superoxide anion;   

DOI  :  10.3390/md10051156

来源: mdpi

【 摘 要 】

Two new briarane diterpenoids, briarenolides, F (1) and G (2), were isolated from an octocoral identified as Briareum sp. The structures of briaranes 1 and 2 were established by spectroscopic methods and by comparison of the spectroscopic data with those of known briarane analogues. Briarenolide F was proven to be the first 6-hydroperoxybriarane derivative and this compound displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.