Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)

Marine Drugs

Yin-Di Su²  Tung-Ying Wu³  Zhi-Hong Wen²  Ching-Chyuan Su¹  Yu-Hsin Chen⁴  Yu-Chia Chang⁴  Yang-Chang Wu³  Jyh-Horng Sheu²  Ping-Jyun Sung² 

[1] Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan;Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan;Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan;National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan;

关键词: Briareum;    briarane;    octocoral;    anti-inflammatory;    iNOS;    COX-2;   

DOI  :  10.3390/md13127060

来源: mdpi

【 摘 要 】

Five new 13,14-epoxybriarane diterpenoids, briarenolides U–Y (1–5), were isolated from the octocoral Briareum sp. The structures of briaranes 1–5 were elucidated by spectroscopic methods. Briarenolides U–Y (1–5) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.