Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum

Molecules

卷:22

Kuan-Hao Tsui¹  Nan-Fu Chen²  Zhi-Hong Wen³  Tsong-Long Hwang⁴  Yang-Chang Wu⁵  Yin-Di Su⁶  Zuo-Jian Liao⁶  Ping-Jyun Sung⁶ 

[1] Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan;

[2] Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan;

[3] Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University and Academia Sinica, Kaohsiung 804, Taiwan;

[4] Graduate Institute of Natural Products, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan;

[5] Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan;

[6] National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan;

关键词: Briareum excavatum;    octocoral;    briarane;    briarenol;    anti-inflammatory;    elastase;    iNOS;   

DOI  :  10.3390/molecules22030475

来源: DOAJ

【 摘 要 】

Three new polyoxygenated briarane diterpenoids, briarenols C–E (1–3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC50 value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).

【 授权许可】

Unknown