Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum

Marine Drugs

Ping-Jyun Sung⁴  Bo-Yuan Chen⁴  Mei-Ru Lin³  Tsong-Long Hwang¹  Wei-Hsien Wang³  Jyh-Horng Sheu² 

[1] Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mail:;National Museum of Marine Biology & Aquarium, Checheng, Pingtung 944, Taiwan; E-Mails:;Graduate Institute of Marine Biotechnology and Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan; E-Mail:

关键词: excavatoid;    briarane;    octocoral;    Briareum excavatum;    human neutrophil;   

DOI  :  10.3390/md7030472

来源: mdpi

【 摘 要 】

Two new briarane-related diterpenoids, designated as excavatoids E (1) and F (2), were isolated from the cultured octocoral Briareum excavatum. The structures of compounds 1 and 2 were established on the basis of extensive spectral data analysis. Briaranes 1 and 2 were found to exhibit moderate inhibitory effects on elastase release by human neutrophils.

【 授权许可】

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland