Helminth lipidomics: Technical aspects and future prospects

Current Research in Parasitology and Vector-Borne Diseases

Shuai Nie¹  Gavin E. Reid²  Tao Wang³  Robin B. Gasser⁴ 

[1] Corresponding author. Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.;Bio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, Victoria 3010, Australia;Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia;School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010 Australia;

关键词: Lipid (fat);    Lipidome;    Lipidomics;    Mass spectrometry;    Parasitic worm;    Helminth;   

DOI  :  

来源: DOAJ

【 摘 要 】

Lipidomics is a relatively recent molecular research field, and explores lipids (fats) and their biology using advanced mass spectrometry technologies. Although this field has expanded significantly in biomedical and biotechnological disciplines, it is still in its infancy in molecular parasitology. Our goal here is to review and discuss technical aspects of MS-based lipidomics and its recent applications to parasitic worms, as well as challenges and future directions for worm lipid research. In a multi-omic paradigm, we expect that the exploration of lipidomic data for parasitic worms will yield important insights into lipid-associated biological pathways and processes, including the regulation of essential signalling pathways, parasite invasion, establishment, adaptation and development.

【 授权许可】

Unknown