Evaluation of antifertility effect of the seed oil constituents of Iranian species of Melia azadarach L. in male rats

Journal of Medicinal Plants

HR Sadeghipour¹  H Sepehri¹  R Parandine²  SA Haeri Rohani²  M Vosooghi³  A Hadjiakhoondi⁴  M Khanavi⁴ 

[1] 1-Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran;2-Depatment of animal Physiology, Faculty of Sciences, Tehran University, Tehran;3-Depatment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Tehran University of Medical Science, Tehran, Iran;4-Department of Pharmacognosy, Faculty of Pharmacy and Medicinal plants Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran;

关键词: male rats;    antifertility;    melia azadarach l.;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Convenient and effective contraceptive methods have been the subject of extensive and versatile research project, during the past 50 years. In this respect, the use of active herbal constituents is one of the topics of research and investigation. Objective: In this study the antifertility activity of seed oil extract of Iranian species of Melia azadarach L. in northern district of country, on male rats, during 2 consecutive steps have been evaluated. Method: The seed oil extract have been prepared according to conventional methods, and were administered orally in 50 and 100 mg/kg daily doses for 60 days. In the first step, the inhibition of fertility indices were assessed with the help of, sperm viability, sperm motility, ESR (Epididymal sperm reserves), DSP (Daily sperm production), GSI (Gonado stomatic index), fertility indices, and serum testosterone content. In the subsequent stage, 3 months after the 60th day of compounds administration, the reversibility of the a formentioned indices are determined again. Result: In the first step, a significant reduction in fertility indices to control especially in higher dose were observed. During the next stage, the significant increase in fertility indices are the indication of reasonable recovery and reversibility of extract activity. Conclusion: In summery, the result of this study of this study showed that its activity is reversible.

【 授权许可】

Unknown