Sodium fluoride does not alter sperm production or sperm morphology in rats

Brazilian Archives of Biology and Technology

Lea Rosa Chioca¹  Juliane Centeno Müller¹  Ana Cláudia Boareto¹  Roberto Andreatini¹  Paulo Roberto Dalsenter¹ 

[1] ,Universidade Federal do Paraná Departamento de Farmacologia Curitiba PR ,Brasil

关键词: Fluoride;    sodium fluoride;    male rats;    reproductive toxicology;    dental fluorosis;    sperm;   

DOI  :  10.1590/S1516-89132012000200011

来源: SciELO

【 摘 要 】

The aim of the present study was to evaluate the effects of sodium fluoride (NaF) on the male reproductive system. Adult male rats were exposed to NaF in drinking water for 30 days at three concentrations: 1.54 (control, tap water), 50 and 100 ppm. Body and organ weights, daily sperm production, sperm number and morphology were investigated. No difference was observed on the sperm number and morphology among the groups, as well as body weight and organ absolute and relative weights. Overall, despite the presence of a mild degree of dental fluorosis in the higher dose group, the results indicated that exposure to NaF at the doses used in the present study did not adversely affect sperm production and morphology of male rats.

【 授权许可】

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