A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer

Nutrients

Witold Jeleniewicz¹  Małgorzata Guz¹  Izabela Korona-Glowniak²  Anna Malm² 

[1] Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland;Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland;

关键词: nutrition;    diet;    gut microbiota;    gut microbiota-derived metabolites;    miRNAs;    epigenetic;   

DOI  :  10.3390/nu13072428

来源: DOAJ

【 摘 要 】

A still growing interest between human nutrition in relation to health and disease states can be observed. Dietary components shape the composition of microbiota colonizing our gastrointestinal tract which play a vital role in maintaining human health. There is a strong evidence that diet, gut microbiota and their metabolites significantly influence our epigenome, particularly through the modulation of microRNAs. These group of small non-coding RNAs maintain cellular homeostasis, however any changes leading to impaired expression of miRNAs contribute to the development of different pathologies, including neoplastic diseases. Imbalance of intestinal microbiota due to diet is primary associated with the development of colorectal cancer as well as other types of cancers. In the present work we summarize current knowledge with particular emphasis on diet-microbiota-miRNAs axis and its relation to the development of colorectal cancer.

【 授权许可】

Unknown