Microvascular Tissue Engineering—A Review

Biomedicines

Marko Milojević¹  Uroš Maver¹  Boštjan Vihar¹  Jernej Vajda¹ 

[1] Faculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia;

关键词: regenerative medicine;    tissue engineering;    vascularization;    biomaterials;    microvascularization;    coculture;   

DOI  :  10.3390/biomedicines9060589

来源: DOAJ

【 摘 要 】

Tissue engineering and regenerative medicine have come a long way in recent decades, but the lack of functioning vasculature is still a major obstacle preventing the development of thicker, physiologically relevant tissue constructs. A large part of this obstacle lies in the development of the vessels on a microscale—the microvasculature—that are crucial for oxygen and nutrient delivery. In this review, we present the state of the art in the field of microvascular tissue engineering and demonstrate the challenges for future research in various sections of the field. Finally, we illustrate the potential strategies for addressing some of those challenges.

【 授权许可】

Unknown