Tissue engineering and regenerative medicine –where do we stand?

Journal of Cellular and Molecular Medicine

Raymund E. Horch¹  Ulrich Kneser¹  Elias Polykandriotis¹  Volker J. Schmidt¹  Jiaming Sun² 

[1] Department of Plastic and Hand Surgery And Laboratory for Tissue Engineering and Regenerative Medicine, Friedrich Alexander University Erlangen-Nuernberg, Erlangen, Germany;Plastic Surgery Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

关键词: tissue engineering;    regenerative medicine;    cell transplantation;    gene transfer;    mesenchymal stem cells;    AV loop;    vascularization;    angiogenesis;    telocytes;    embryonal stem cells;   

DOI  :  10.1111/j.1582-4934.2012.01564.x

来源: Wiley

【 摘 要 】

Abstract

• Introduction
• Intrinsic and extrinsic vascularization of TE constructs – the AV-loop model
• Gene Transfer Techniques
• Combining mesenchymal stem cells with the AV-loop model of intrinsic vascularization
• TE and RM in the context of Cancer Research
• Newly discovered cells of potential benefit for RM
• Summary

Tissue Engineering (TE) in the context of Regenerative Medicine (RM) has been hailed for many years as one of the most important topics in medicine in the twenty-first century. While the first clinically relevant TE efforts were mainly concerned with the generation of bioengineered skin substitutes, subsequently TE applications have been continuously extended to a wide variety of tissues and organs. The advent of either embryonic or mesenchymal adult stem-cell technology has fostered many of the efforts to combine this promising tool with TE approaches and has merged the field into the term Regenerative Medicine. As a typical example in translational medicine, the discovery of a new type of cells called Telocytes that have been described in many organs and have been detected by electron microscopy opens another gate to RM. Besides cell-therapy strategies, the application of gene therapy combined with TE has been investigated to generate tissues and organs. The vascularization of constructs plays a crucial role besides the matrix and cell substitutes. Therefore, novel in vivo models of vascularization have evolved allowing axial vascularization with subsequent transplantation of constructs. This article is intended to give an overview over some of the most recent developments and possible applications in RM through the perspective of TE achievements and cellular research. The synthesis of TE with innovative methods of molecular biology and stem-cell technology appears to be very promising.

【 授权许可】

Unknown   
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd