Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload

Neural Regeneration Research

关键词: active zone stability;    Drosophila;    neuromuscular junction;    dephosphorylation;    Liprin-α;    Syd-1;    PP2A;    GSK-3ß;    living scaffolds;    neural tissue engineering;    cell transplant;    biomaterials;    regeneration;    neurotrauma;    neurodegeneration;    axon pathfinding;    cell migration;    injury;    plasticity;    neurodegenerative disease;    brain;    therapy;    neuron;    microglia;    neural progenitor;    tissue engineering;    neuroregeneration;    repair;    central nervous system;    biomaterial;    regenerative medicine;    nanotechnology;    spinal cord injury;    axonal regeneration;    exosome;    extracellular vesicle;    microRNA;    microvesicle;    nerve gap;    neurite outgrowth;    peripheral nerve injury;    Schwann cell;    stem cell;    hemodynamic phases;    cerebral subarachnoid hemorrhage;    metabolic crises;    nerve regeneration;    hypoxic-ischemic brain damage;    ginsenoside Rg1;    neural stem cells;    cell transplantation;    cell differentiation;    cognition;    nerve reconstruction;    neural regeneration;    nerve regeneration;    brain injury;    neuroimaging;    functional magnetic resonance imaging;    regional homogeneity;    apoplexy;    subacute;    ischemia;    participants;    healthy;    volunteers;    brain activity;    NSFC grants;    neural regeneration;    nerve regeneration;    brain injury;    neuroprotection;    cerebral ischemia/reperfusion injury;    lateral intracerebroventricular injection;    Apelin-13;    nerve apoptosis;    Bcl-2;    caspase-3;    NSFC grants;    neural regeneration;    nerve regeneration;    fractalkine;    CX3 chemokine receptor 1;    neuronal maturation;    dendrites;    doublecortin;    synaptic maturation;    newborn neurons;    neural regeneration;    nerve regeneration;    neurodegenerative diseases;    Alzheimer′s disease;    transgenic animal models;    mice;    epimedium herb;    milkvetch root;    kudzuvine root;    divalent metal transporter 1;    ferroportin 1;    neural regeneration;   

DOI  :  10.4103/1673-5374.156981

来源: DOAJ

【 摘 要 】

Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer′s disease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer′s disease patients. An APP swe/PS1ΔE9 double transgenic mouse model of Alzheimer′s disease was used. The intragastric administration of compounds from epimedium herb, milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema, increased the number of neurons, downregulated divalent metal transporter 1 expression, upregulated ferroportin 1 expression, and inhibited iron overload in the cerebral cortex of mice with Alzheimer′s disease. These compounds reduced iron overload-induced impairment of the central nervous system, indicating a new strategy for developing novel drugs for the treatment of Alzheimer′s disease.

【 授权许可】

Unknown