Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Michal Schnaider Beeri¹  Rebecca K. West¹  Anthony Heymann²  Amir Tirosh³  Ramit Ravona‐Springer⁴  Sigalit Manzali⁴  Sapir Golan⁴  Ithamar Ganmore⁴  Inbal Sharvit‐Ginon⁴  Ethel Boccara⁴ 

[1] Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA;Maccabi Healthcare Services Tel Aviv Israel;Sackler School of Medicine Tel Aviv University Tel Aviv Israel;The Joseph Sagol Neuroscience Center Sheba Medical Center Tel‐Hashomer Israel;

关键词: adiposity;    Alzheimer's disease;    cognition;    cognitive decline;    obesity;    parental history of Alzheimer's disease;   

DOI  :  10.1002/dad2.12247

来源: DOAJ

【 摘 要 】

Abstract Introduction We examined relationships of body mass index (BMI) with cognition in middle‐aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long‐term trajectories of BMI with cognition. Results Higher BMI was associated with worse language (P = .045). Interactions of BMI with parental history were significant for episodic memory (P = .023), language (p = .027), working memory (P = .006), global cognition (P = .008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P = .017), language (P = .013), working memory (P = .001), global cognition (P = .005), with stronger associations for maternal history. Discussion Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.

【 授权许可】

Unknown