Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population

Aging Cell

Anne M Murray¹  Moeen Riaz²  Paul Lacaze²  Elsdon Storey²  Rory Wolfe²  Suzanne G Orchard²  Robyn L. Woods²  Jane Tiller²  Jessica Lockery²  John J. McNeil²  Joanne Ryan²  Aamira Huq³  Raj C. Shah⁴  Robert Sebra⁵  Eric Schadt⁵  Amy Brodtmann⁶  Alan E. Renton⁷  Alison M. Goate⁷ 

[1] Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, University of Minnesota, Minneapolis, MN, USA;Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia;Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia;Department of Genomic Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia;Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia;Department of Family Medicine and Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA;Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;Florey Institute of Neuroscience and Mental Health, Melbourne, Vic, Australia;Melbourne Dementia Research Centre, University of Melbourne, Melbourne, Vic, Australia;Nash Family Department of Neuroscience and Ronald Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA;Departments of Neurology and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA;

关键词: Alzheimer's disease;    Apolipoprotein E;    aspirin in reducing events in the elderly;    cognition;    cognitive decline;    cumulative incidence of dementia;    genome‐wide association study;    polygenic risk score;   

DOI  :  10.1111/acel.13384

来源: Wiley

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