Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype

FEBS Letters

Frangione, Blas¹  Abee, Christian R.⁴  Walker, Lary C.²  Levy, Efrat³  Wei, LiHong³  Amorim, Angela³  McDermid, Jeanine³  Morelli, Laura¹ 

[1]Department of Pathology, New York University Medical Center, 550 First Avenue, MSB 249, New York, NY 10016, USA

[2]Neuropathology Laboratory, Department of Pathology, The Johns Hopkins University School of Medicine, 558 Ross Bldg., 720 Rutland Ave., Baltimore, MD 21205, USA

[3]Department of Pharmacology, New York University Medical Center, 550 First Avenue, MSB 249, New York, NY 10016, USA

[4]Department of Comparative Medicine, University of South Alabama School of Medicine, Mobile, AL 36688, USA

关键词: Aging;    Alzheimer's disease;    Amyloid;    Apolipoprotein E;    AD;    Alzheimer's disease;    apoE;    apolipoprotein E;    CAA;    cerebral amyloid angiopathy;    SCAA;    sporadic cerebral amyloid angiopathy;    Aβ;    β-amyloid;    βPP;    β-amyloid precursor protein;    HCHWA-D;    hereditary cerebral hemorrhage with amyloidosis Dutch type;   

DOI  :  10.1016/0014-5793(95)01491-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Some neuropathological changes characteristic of aging and Alzheimer's disease (AD) in humans are present also in senescent non-human primates. The human apoE4 allele is associated with an increased risk of developing late-onset familial and sporadic AD. We found that rhesus monkeys and three subspecies of squirrel monkeys are homozygous for apoE phenotype with arginine at positions 112 and 158 as in human apoE4. However, in both species threonine replaces arginine at position 61 of human apoE. It was previously shown that arginine 61 was critical in determining apoE4 lipoprotein distribution in humans.

【 授权许可】

Unknown