Frontotemporal dementia is the leading cause of “true” A−/T+ profiles defined with Aβ42/40 ratio

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Tri‐Bao Nguyen¹  Emilie Skrobala²  Hélène Pouclet‐Courtemanche³  Claire Boutoleau‐Bretonnière³  Edith Bigot‐Corbel⁴  Claire Paquet⁵  Julien Dumurgier⁵  Elodie Bouaziz‐Amar⁶  Florence Pasquier⁷  Susanna Schraen⁸  Thibaud Lebouvier⁸ 

[1] CH DelafontaineSaint‐DenisFrance;CHU Lille, DISTALZLilleFrance;CHU NantesInserm CIC04, Department of NeurologyCentre Mémoire de Ressources et RechercheNantesFrance;CHU de Nantes, Laboratory of BiochemistryNantesFrance;Cognitive Neurology Center, Lariboisiere ‐ Fernand Widal Hospital, AP‐HP, Université Paris DiderotSorbonne Paris CitéParisFrance;Département de Biochimie et de biologie moléculaire GH Saint‐Louis/Lariboisière/Fernand Widal ‐ Site LariboisièreAP‐HPParisFrance;University of Lille, Inserm U1171, CHU Lille, DISTALZLilleFrance;University of Lille, Inserm U1172, CHU Lille, DISTALZLilleFrance;

关键词: Alzheimer's disease;    Cerebrospinal fluid biomarkers;    Aβ42/40 ratio;    Aβ42/Aβ40 ratio;    Frontotemporal dementia;    Suspected non Alzheimer's disease pathology (SNAP);   

DOI  :  10.1016/j.dadm.2019.01.001

来源: DOAJ

【 摘 要 】

Abstract Introduction Patients with positive tauopathy but negative Aβ42 (A−T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ42/40 ratio supersedes Aβ42 and reintegrates “false” A−T+ patients into the Alzheimer's disease spectrum. However, the biomarker and clinical characteristics of “true” and “false” A−T+ patients remain elusive. Methods Among the 509 T+N+ patients extracted from the databases of three memory clinics, we analyzed T+N+ patients with normal Aβ42 and compared “false” A−T+ with abnormal Aβ42/40 ratio and “true” A−T+ patients with normal Aβ42/40 ratio, before CSF analysis and at follow‐up. Results 24.9% of T+N+ patients had normal Aβ42 levels. Among them, 42.7% were “true” A−T+. “True” A−T+ had lower CSF tauP181 than “false” A−T+ patients. 48.0% of “true” A−T+ patients were diagnosed with frontotemporal lobar degeneration before CSF analysis and 64.0% at follow‐up, as compared with 6% in the “false” A−T+ group (P < .0001). Discussion Frontotemporal lobar degeneration is probably the main cause of “true” A−T+ profiles.

【 授权许可】

Unknown