Muscle and Bone Health in Postmenopausal Women: Role of Protein and Vitamin D Supplementation Combined with Exercise Training

Nutrients

Piero Sestili¹  Elena Barbieri¹  Marco Gervasi¹  Francesco Lucertini¹  Giosuè Annibalini¹  Sabrina Donati Zeppa¹  Giovanni Piccoli¹  Vilberto Stocchi¹  Deborah Agostini¹  Carlo Ferri Marini¹ 

[1] Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 (PU) Urbino, Italy;

关键词: postmenopausal women;    sarcopenia;    osteoporosis;    exercise;    dietary protein;    vitamin D;   

DOI  :  10.3390/nu10081103

来源: DOAJ

【 摘 要 】

Menopause is an age-dependent physiological condition associated with a natural decline in oestrogen levels, which causes a progressive decrease of muscle mass and strength and bone density. Sarcopenia and osteoporosis often coexist in elderly people, with a prevalence of the latter in elderly women. The profound interaction between muscle and bone induces a negative resonance between the two tissues affected by these disorders worsening the quality of life in the postmenopausal period. It has been estimated that at least 1 in 3 women over age 50 will experience osteoporotic fractures, often requiring hospitalisation and long-term care, causing a large financial burden to health insurance systems. Hormonal replacement therapy is effective in osteoporosis prevention, but concerns have been raised with regard to its safety. On the whole, the increase in life expectancy for postmenopausal women along with the need to improve their quality of life makes it necessary to develop specific and safe therapeutic strategies, alternative to hormonal replacement therapy, targeting both sarcopenia and osteoporosis progression. This review will examine the rationale and the effects of dietary protein, vitamin D and calcium supplementation combined with a specifically-designed exercise training prescription as a strategy to counteract these postmenopausal-associated disorders.

【 授权许可】

Unknown