Regular Exercise Decreases the Risk of Osteoporosis in Postmenopausal Women

Frontiers in Public Health

article

Chu-Fen Chang¹  Jia-In Lee²  Shu-Pin Huang³  Jiun-Hung Geng³  Szu-Chia Chen⁷ 

[1] Department of Physical Therapy, Tzu Chi University;Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University;Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University;Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University;Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University;Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University;Research Center for Environmental Medicine, Kaohsiung Medical University;Department of Urology, Kaohsiung Municipal Siaogang Hospital;Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University;Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University;Faculty of Medicine, College of Medicine, Kaohsiung Medical University

关键词: osteoporosis;    exercise;    postmenopausal women;    epidemiologic study;    risk factors;   

DOI  :  10.3389/fpubh.2022.897363

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Regular exercise can regulate bone maintenance and improve bone health. However, large-scale epidemiological studies on the association between regular exercise and incident osteoporosis in menopausal women are still lacking. We aimed to examine the relationship between exercise and the risk of osteoporosis in menopausal women. In cross-sectional analysis, we enrolled 30,046 postmenopausal women with available information from the database of the Taiwan Biobank (TWB). We divided them into two groups according to their status of regular exercise, i.e., no exercise and regular exercise groups. A t -score of −2.5 or more standard deviations (SDs) below that of a young adult was defined as osteoporosis. Logistic regression after adjusting for confounding factors was used to analyze the association between regular exercise and the prevalence of osteoporosis. Furthermore, the risk of incident osteoporosis development was analyzed in a longitudinal cohort of 6,785 postmenopausal women without osteoporosis at baseline using a Kaplan-Meier analysis and a log-rank test. The mean age of subjects in the cross-sectional cohort was 59 years old. Fifty-six percent of them were exercising regularly. Osteoporosis was observed in 1,886 (14.2%) and 2,254 (13.4%) participants in the no exercise and regular exercise groups. Lower risk of osteoporosis was noted in postmenopausal women with regular exercise when compared with those without regular exercise [odds ratio (OR), 0.76; 95% confidence interval (95% CI), 0.71–0.81]. In the longitudinal cohort, incident osteoporosis was found in 430 (10.5%) women with regular exercise and 299 (11.2%) women without exercise during a mean follow-up of 45 months. Cox regression analysis revealed that the risk for incident osteoporosis was lower in postmenopausal women with regular exercise than those without exercise [hazard ratio (HR), 0.83; 95% CI, 0.71–0.97]. Our study suggests that regular exercise is associated with a reduced risk of osteoporosis in postmenopausal women and strengthens the importance of exercise for the prevention of osteoporosis.

【 授权许可】

CC BY