Cichorins D-F: Three New Compounds from Cichorium intybus and Their Biological Effects

Molecules

Mohamad Saoud¹  Hidayat Hussain¹  Robert Rennert¹  Mthandazo Dube¹  Wahid Hussain²  IvanR. Green³  OmerAhmed M. Basudan⁴  MuhammadFarooq Khan⁵  ShamsaHilal Anazi⁵  NoufAbdulaziz Alyhya⁵  FahdA. Nasr⁶  Riaz Ullah⁶  OmarM. Noman⁶  Iftikhar Ali⁷ 

[1] Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Salle), Germany;Department of Botany, Government Post Graduate College Parachinar, Parachinar 26300, District Kurram, Pakistan;Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch 7600, South Africa;Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China;

关键词: Cichorium intybus;    Asteraceae;    naphthalene;    anthraquinone;    natural product;    cytotoxic effects;   

DOI  :  10.3390/molecules25184160

来源: DOAJ

【 摘 要 】

Cichorium intybus L., (chicory) is employed in various traditional medicines to treat a wide range of diseases and disorders. In the current investigation, two new naphthalane derivatives viz., cichorins D (1) and E (2), along with one new anthraquinone cichorin F (3), were isolated from Cichorium intybus. In addition, three previously reported compounds viz., β-sitosterol (4), β-sitosterol β-glucopyranoside (5), and stigmasterol (6) were also isolated from Cichorium intybus. Their structures were established via extensive spectroscopic data, including 1D (¹H and ¹³C) and 2D NMR (COSY, HSQC and HMBC), and ESIMS. Cichorin E (2) has a weak cytotoxic effect on breast cancer cells (MDA-MB-468: IC₅₀: 85.9 µM) and Ewing’s sarcoma cells (SK-N-MC: IC₅₀: 71.1 µM); cichorin F (3) also illustrated weak cytotoxic effects on breast cancer cells (MDA-MB-468: IC₅₀: 41.0 µM and MDA-MB-231: IC₅₀: 45.6 µM), and SK-N-MC cells (IC₅₀: 71.9 µM). Moreover compounds 1–3 did not show any promising anthelmintic effects.

【 授权许可】

Unknown