Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines

Molecules

Hui Zhang¹  Zengjun Guo¹  Nan Wu¹  Wenming Xu¹  Ling Han¹  Nan Li¹ 

[1] Faculty of Pharmacy, School of Medicine, Xi'an Jiaotong University, No. 76 West Yanta Road, Xi'an 710061, China

关键词: naphthalene;    glucoside;    anthraquinone;    Rumex dentatus;    antiproliferation;   

DOI  :  10.3390/molecules17010843

来源: mdpi

【 摘 要 】

An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-glucoside (3) were found in the plant for the first time. Compounds 2 and 3 are novel compounds. Their antiproliferation activities were tested by the MTT assay in four cell lines (breast cancer MCF-7, gastric cancer 7901, melanoma A375 and oophoroma SKOV-3).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.