Mechanism for Clastogenic Activity of Naphthalene

Buchholz, Bruce A.¹ 

[1]Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

关键词: naphthalene;    DNA adducts;    clastogen;    metabolite;   

DOI  :  10.2172/1281678
RP-ID  :  LLNL-TR--695881
PID  :  OSTI ID: 1281678

美国|英语

来源: SciTech Connect

【 摘 要 】

Naphthalene incubations form DNA adducts in vitro in a dose dependent manner in both mouse and rat tissues. Rodent tissue incubations with naphthalene indicate that naphthalene forms as many DNA adducts as Benzo(a)pyrene, a known DNA binding carcinogen. The mouse airway has the greatest number of DNA adducts, corresponding to the higher metabolic activation of naphthalene in this location. Both rat tissues, the rat olfactory (tumor target) and the airways (non-tumor target), have similar levels of NA-DNA adducts, indicating that short term measures of initial adduct formation do not directly correlate with sites of tumor formation in the NTP bioassays.