Cytotoxic Quinones from the Roots of Aloe dawei

Molecules

Negera Abdissa¹  Martha Induli¹  Paul Fitzpatrick³  John Patrick Alao²  Per Sunnerhagen²  Göran Landberg³  Abiy Yenesew¹ 

[1] Department of Chemistry, University of Nairobi, P.O. Box 30197, Nairobi 00100, Kenya; E-Mails:;Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden; E-Mails:;Sahlgrenska Cancer Centre, University of Gothenburg, Gothenburg SE-405 30, Sweden; E-Mails:

关键词: Aloe dawei;    Asphodelaceae;    naphthoquinone;    anthraquinone;    6-hydroxy-3;    5-dimethoxy-2-methyl-1;    4-naphthoquinone;    cytotoxicity;    MCF-7;   

DOI  :  10.3390/molecules19033264

来源: mdpi

【 摘 要 】

Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC₅₀ 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.